Hallo,
bedankt voor de reactie, ik heb zonet even het keyboard losgekoppeld maar dat hielp ook niet (of schakel ik de mac beter uit en in?)
Gisteren heb ik een etre check doorlopen, maar ik ken er te weinig van om het te begrijpen, hieronder is het rapport:
Frank 
EtreCheckPro version: 6.8.7 (68068)
Report generated: 2024-12-17 08:43:59
Download EtreCheckPro from 
https://etrecheck.comRuntime: 10:36
Performance: Below Average
Problem: Other problem
Description: 
Cursor doesn’t change to pointed finger
Major Issues:
  Anything that appears on this list needs immediate attention. 
  Unsigned files - There are unsigned software files installed that could be malicious and should be reviewed.
  Obsolete hardware - This computer may be considered obsolete.
Minor Issues:
  These issues do not need immediate attention but they may indicate future problems or opportunities for improvement. 
  System extensions installed - This computer has system extensions installed. System extensions can be difficult to uninstall.
  No Time Machine backup - Time Machine backup not found.
  Apps crashing - There have been numerous app crashes.
  Apps with heavy CPU usage - There have been numerous cases of apps with heavy CPU usage.
  Clean up - There are orphan files that could be removed.
  Low performance - EtreCheck report took an unusually long time to run.
  External drives and performance - There are external drives connected that could be affecting performance.
  Limited permissions - More information may be available with Full Disk Access.
  Kernel extensions present - This computer has kernel extensions that may not work in the future.
  Sharing enabled - This computer has sharing services enabled that could be a security risk.
Hardware Information:
  iMac (Retina 5K, 27-inch, Late 2014)
    Status: Obsolete
  iMac Model: iMac15,1
  4 GHz Quad-Core Intel Core i7 (i7-4790K) CPU: 4-core
  16 GB RAM - Upgradeable
    BANK 0/DIMM0 - 8 GB DDR3 1600  
    BANK 1/DIMM0 - 8 GB DDR3 1600  
    BANK 0/DIMM1 - Empty   
    BANK 1/DIMM1 - Empty   
Video Information:
  AMD Radeon R9 M295X - VRAM: 4 GB
    iMac (built-in) 5120 x 2880
Drives:
  disk0 - APPLE SSD SM0128G 121.33 GB (Solid State - TRIM: Yes) 
  Internal PCI 5.0 GT/s x2 Serial ATA
    disk0s1 - EFI (MS-DOS FAT32) [EFI] 210 MB
    disk0s2 [APFS Fusion Drive] 121.12 GB
      disk2 [APFS Virtual drive] 2.12 TB (Shared by 6 volumes)
        disk2s1 - m***************************s (APFS) [APFS Virtual drive] (580.13 GB used)
        disk2s2 - Preboot (APFS) [APFS Preboot] (429 MB used)
        disk2s3 - Recovery (APFS) [Recovery] (621 MB used)
        disk2s4 - VM (APFS) [APFS VM] (2.15 GB used)
        disk2s5 (APFS) [APFS Container] (15.32 GB used)
          disk2s5s1 - m****************2 (APFS) [APFS Snapshot] (15.32 GB used)
        disk2s6 - Update (APFS) (12 MB used)
  disk1 - WDC WD2003FZEX-00SRLA0 2.00 TB (Mechanical - 7200 RPM) 
  Internal SATA 6 Gigabit Serial ATA
    disk1s1 - EFI (MS-DOS FAT32) [EFI] 210 MB
    disk1s2 [APFS Fusion Drive] 2.00 TB
      disk2 [APFS Virtual drive] 2.12 TB (Shared by 6 volumes)
        disk2s1 - m***************************s (APFS) [APFS Virtual drive] (580.13 GB used)
        disk2s2 - Preboot (APFS) [APFS Preboot] (429 MB used)
        disk2s3 - Recovery (APFS) [Recovery] (621 MB used)
        disk2s4 - VM (APFS) [APFS VM] (2.15 GB used)
        disk2s5 (APFS) [APFS Container] (15.32 GB used)
          disk2s5s1 - m****************2 (APFS) [APFS Snapshot] (15.32 GB used)
        disk2s6 - Update (APFS) (12 MB used)
  disk3 - LaCie P9233 4.00 TB
  External USB Up to 5 Gb/s USB
    disk3s1 - EFI [EFI] 315 MB
    disk3s2 - l*******b (Journaled HFS+) 4.00 TB (2.93 TB used)
  disk4 - LaCie P9237 Desktop 6.00 TB (Mechanical) 
  External USB Up to 5 Gb/s USB
    disk4s1 - EFI (MS-DOS FAT32) [EFI] 210 MB
    disk4s2 - l********b (Journaled HFS+) 6.00 TB (5.43 TB used)
Mounted Volumes:
  disk2s1 - m***************************s [APFS Virtual drive]
    Filesystem: APFS
    Mount point: /System/Volumes/Data
    Fusion drive
    Used: 580.13 GB
    Shared values
      Size: 2.12 TB
      Free: 1.51 TB
      Available: 1.52 TB
  disk2s2 - Preboot [APFS Preboot]
    Filesystem: APFS
    Mount point: /System/Volumes/Preboot
    Fusion drive
    Used: 429 MB
    Shared values
      Size: 2.12 TB
      Free: 1.51 TB
  disk2s4 - VM [APFS VM]
    Filesystem: APFS
    Mount point: /System/Volumes/VM
    Fusion drive
    Used: 2.15 GB
    Shared values
      Size: 2.12 TB
      Free: 1.51 TB
  disk2s5s1 - m****************2 [APFS Snapshot]
    Filesystem: APFS
    Mount point: /
    Fusion drive
    Read-only: Yes
    Used: 15.32 GB
    Shared values
      Size: 2.12 TB
      Free: 1.51 TB
      Available: 1.52 TB
  disk2s6 - Update
    Filesystem: APFS
    Mount point: /System/Volumes/Update
    Fusion drive
    Used: 12 MB
    Shared values
      Size: 2.12 TB
      Free: 1.51 TB
  disk3s2 - l*******b
    Filesystem: Journaled HFS+
    Mount point: /Volumes/l*******b
    Owners enabled: No
    Used: 2.93 TB
    Size: 4.00 TB
    Free: 1.07 TB
  disk4s2 - l********b
    Filesystem: Journaled HFS+
    Mount point: /Volumes/l********b
    Owners enabled: No
    Used: 5.43 TB
    Size: 6.00 TB
    Free: 573.34 GB
    Available: 573.51 GB
USB:
  USB 3.0 bus
    LaCie - P9233
    LaCie - P9237 Desktop
    Apple Inc. - BRCM20702 Hub
      Apple Inc. - Bluetooth USB Host Controller
    Apple Inc. - FaceTime HD Camera (Built-in)
    USB2.0 Hub
      Matias Keyboard - Matias Wired Keyboard
Network:
  Interface en0: Ethernet
  Interface en1: Wi-Fi
    802.11 a/b/g/n/ac
  Interface en4: Bluetooth PAN
  Interface bridge0: Thunderbolt Bridge
  Printer sharing: Enabled
System Software:
  macOS Big Sur 11.7.10 (20G1427) 
  Time since boot: About 2 hours
Security:
  Gatekeeper: App Store and identified developers
  System Integrity Protection: Enabled
  Antivirus software: Apple and Sophos
  Printer sharing: Enabled
Unsigned Files:
  Launchd: ~/Library/LaunchAgents/com.adobe.GC.Invoker-1.0.plist
    Command: /Library/Application Support/Adobe/AdobeGCClient/agcinvokerutility -mode=scheduled
    Details: Exact match found in the legitimate list - probably OK
  Launchd: /Library/LaunchDaemons/com.olympus.AuthHelper3.helper.plist
    Executable: /Library/PrivilegedHelperTools/com.olympus.AuthHelper3.helper
  Launchd: /Library/LaunchAgents/com.brother.LOGINserver.plist
    Executable: /Library/Printers/Brother/Utilities/Server/LOGINserver.app/Contents/MacOS/LOGINserver
    Details: Exact match found in the legitimate list - probably OK
  Running app: /Library/Printers/Brother/Utilities/Server/NETserver.app/Contents/MacOS/NETserver
    Details: Gatekeeper bypass
  Running app: /Library/Printers/Brother/Utilities/Server/USBserver.app/Contents/MacOS/USBserver
    Details: Gatekeeper bypass
  Apps: 12
System Extensions:
  [Running] networkextension - version 10.6.0 (Sophos - installed 2024-02-27)
    Application: /Applications/Sophos/Sophos Network Extension.app - version 10.6.0 (Sophos - installed 2024-02-27)
  [Running] com.sophos.endpoint.scanextension - version 10.6.0 (Sophos - installed 2024-02-27)
    Application: /Applications/Sophos/Sophos Scan.app - version 10.6.0 (Sophos - installed 2024-02-27)
    Description: Scanning Services
Kernel Extensions:
  /Library/Application Support/Logitech.localized/Logitech Options.localized
    [Not Loaded] LogiMgrDriver.kext - com.logitech.manager.kernel.driver (7.12.1 - SDK 10.12)
  /Library/Extensions
    [Not Loaded] OlympusDSCSCSIDriver.kext - com.olympus.CamBlockCommandsDeviceUP (3.3.0 - SDK 10.12)
    [Not Loaded] OMDSCSCSIDriver.kext - com.om-digitalsolutions.CamBlockCommandsDeviceUP (4.2.0 - SDK 11)
System Launch Daemons:
  [Not Loaded]  39 Apple tasks
  [Loaded]  243 Apple tasks
  [Running]  84 Apple tasks
  [Other]  One Apple task
System Launch Agents:
  [Not Loaded]  19 Apple tasks
  [Loaded]  241 Apple tasks
  [Running]  77 Apple tasks
Launch Daemons:
  [Running] com.aladdin.aksusbd.plist (Gemalto, Inc. - installed 2024-02-04)
    Command: /usr/local/sentinel/aksusbd -f
  [Running] com.aladdin.hasplmd.plist (Gemalto, Inc. - installed 2024-02-04)
    Command: /usr/local/sentinel/hasplmd -s -f
  [Loaded] com.apple.installer.osmessagetracing.plist (Apple - installed 2021-05-10)
    Executable: /System/Library/PrivateFrameworks/OSInstaller.framework/Resources/OSMessageTracer
  [Loaded] com.olympus.AuthHelper2.helper.plist (Olympus Corporation - installed 2021-01-19)
    Executable: /Library/PrivilegedHelperTools/com.olympus.AuthHelper2.helper
  [Loaded] com.olympus.AuthHelper3.helper.plist (Not signed - installed 2021-03-11)
    Executable: /Library/PrivilegedHelperTools/com.olympus.AuthHelper3.helper
  [Running] com.sophos.common.servicemanager.plist (Sophos - installed 2024-02-27)
    Executable: /Library/Sophos Anti-Virus/SophosServiceManager.app/Contents/MacOS/SophosServiceManager
  [Not Loaded] com.sophos.sophoscbr.plist (Sophos - installed 2022-08-22)
    Executable: /Library/SophosCBR/SophosCBR.bundle/Contents/MacOS/SophosCBR
  [Running] com.xrite.device.xrdd.plist (X-Rite, Incorporated - installed 2024-02-04)
    Executable: /Library/Application Support/X-Rite/Frameworks/XRiteDevice.framework/Versions/B/Resources/xrdd
  [Loaded] com.xrite.device.xrdd.restart.plist (X-Rite, Incorporated - installed 2024-02-04)
    Command: /bin/sh /Applications/i1Profiler/i1Profiler.app/Contents/Resources/restartXrd.sh
Launch Agents:
  [Not Loaded] com.apple.AuthenticationServicesCore.AuthenticationServicesAgent.plist (Apple - installed 2023-11-09)
    Executable: /Library/Apple/System/Library/CoreServices/SafariSupport.bundle/Contents/MacOS/AuthenticationServicesAgent
  [Running] com.brother.LOGINserver.plist (Not signed - installed 2018-10-18)
    Executable: /Library/Printers/Brother/Utilities/Server/LOGINserver.app/Contents/MacOS/LOGINserver
  [Running] com.logitech.manager.daemon.plist (Logitech Inc. - installed 2024-10-13)
    Command: /Applications/Logi Options.app/Contents/Support/LogiMgrDaemon.app/Contents/MacOS/LogiMgrDaemon --launchd
  [Running] com.sophos.agent.plist (Sophos - installed 2023-09-18)
    Executable: /Library/Sophos Anti-Virus/SophosAgent.app/Contents/MacOS/SophosAgent
  [Running] com.sophos.home.ui.plist (Sophos - installed 2024-02-27)
    Executable: /Applications/Sophos/Sophos Home.app/Contents/MacOS/Sophos Home
  [Loaded] com.xrite.i1Profiler.tray.plist (X-Rite, Incorporated - installed 2024-02-04)
    Command: /usr/bin/open /Applications/i1Profiler/i1ProfilerTray.app
User Launch Agents:
  [Loaded] com.adobe.GC.Invoker-1.0.plist (Not signed - installed 2019-07-23)
    Command: /Library/Application Support/Adobe/AdobeGCClient/agcinvokerutility -mode=scheduled
  [Other] com.adobe.ccxprocess.plist (Not signed - installed 2019-08-20)
    Command: /usr/bin/open -a '/Applications/Utilities/Adobe Creative Cloud Experience/CCXProcess/CCXProcess.app'
  [Loaded] com.google.GoogleUpdater.wake.plist (Google LLC - installed 2024-11-21)
    Command: ~/Library/Application Support/Google/GoogleUpdater/Current/GoogleUpdater.app/Contents/MacOS/GoogleUpdater --wake-all --enable-logging --vmodule=*/components/update_client/*=2,*/chrome/enterprise_companion/*=2,*/chrome/updater/*=2
  [Not Loaded] com.google.keystone.agent.plist (Not signed - installed 2023-12-07)
    <Empty>
  [Not Loaded] com.google.keystone.xpcservice.plist (Not signed - installed 2023-12-07)
    <Empty>
User Login Items:
  [Running] Firefox (Mozilla Corporation - installed 2024-12-12)
    Application
    /Applications/Firefox.app
Applications:
  469 Apple apps
  173 3rd party apps
  142 x86-only apps
  12 unsigned apps
App Extensions:
  Ad-blockers:
    [Loaded] ABP - /Applications/Adblock Plus.app
  Photo editing extensions:
    [Loaded] Luminar 3 - /Applications/Luminar 3.app
    [Loaded] Aurora HDR 2018 - /Applications/Aurora HDR 2018.app
    [Loaded] Affinity Haze Removal - /Applications/Affinity Photo.app
    [Loaded] Affinity Miniature - /Applications/Affinity Photo.app
    [Loaded] Affinity Retouch - /Applications/Affinity Photo.app
    [Loaded] Affinity Develop - /Applications/Affinity Photo.app
    [Loaded] Edit in Affinity Photo - /Applications/Affinity Photo.app
    [Loaded] Affinity Liquify - /Applications/Affinity Photo.app
    [Loaded] Edit in Affinity Photo - /Applications/Affinity Photo 2 2.app
    [Loaded] Affinity Monochrome - /Applications/Affinity Photo.app
  Plugins:
    [Loaded] BEIDToken - /Applications/BEIDToken.app
  Safari extensions:
    [Loaded] ABP Control Panel - /Applications/Adblock Plus.app
  QuickLook Previews (legacy):
    AuroraQuickLook - /Applications/Aurora HDR 2018.app
      com.aurorahdr2018.mpaur2 *.mpaur2
    IIQ - /Applications/Capture One 23.app
      com.leafamerica.raw-image *.mos
      com.phaseone.packaged-image *.eip
      com.phaseone.raw-image *.iiq
    QuickLook - /Applications/Affinity Photo 2 2.app
      com.seriflabs.affinity.package *.afpackage
      com.seriflabs.affinitypublisher.document *.afpub
      com.seriflabs.affinity *.fh10
      com.seriflabs.affinity.template *.aftemplate
      com.seriflabs.affinityphoto.document *.afphoto
      com.seriflabs.affinitypublisher.book *.afbook
      com.seriflabs.affinitydesigner.document *.afdesign
Internet Plug-ins:
  AdobeAAMDetect: 3.0.0.0 (Adobe Systems, Inc. - installed 2019-07-21)
Safari Extensions:
  ABP (App Store - installed 2024-09-12)
  ABP Control Panel (App Store - installed 2024-09-12)
Backup:
  Time Machine information is limited without Full Disk Access
Performance:
  System Load: 1.08 (1 min ago) 1.65 (5 min ago) 2.05 (15 min ago)
  Nominal I/O usage: 0.40 MB/s
  File system: 18.46 seconds
  Write speed: 521 MB/s
  Read speed: 566 MB/s
CPU Usage Snapshot:
  Type Overall
  System: 3 %
  User: 2 %
  Idle: 96 %
Top Processes Snapshot by CPU:
  Process (count) CPU (Source - Location)
  kernel_task 16.00 % (Apple)
  WindowServer 5.56 % (Apple)
  EtreCheckPro 3.84 % (Etresoft, Inc.)
  airportd 3.28 % (Apple)
  configd 0.68 % (Apple)
Top Processes Snapshot by Memory:
  Process (count) RAM usage (Source - Location)
  plugin-container (16) 658 MB (Mozilla Corporation)
  EtreCheckPro 502 MB (Etresoft, Inc.)
  firefox 220 MB (Mozilla Corporation)
  SophosScanD 96 MB (Not signed)
  WindowServer 41 MB (Apple)
Top Processes Snapshot by Network Use:
  Process (count) Input / Output (Source - Location)
  mDNSResponder 15 MB / 14 MB (Apple)
  apsd 4 KB / 116 KB (Apple)
  trustd 102 KB / 7 KB (Apple)
  SophosMcsAgentD 29 KB / 53 KB (Not signed)
  netbiosd 23 KB / 4 KB (Apple)
Top Processes Snapshot by Energy Use:
  Process (count) Energy (0-100) (Source - Location)
  xrdd 4 (X-Rite, Incorporated)
  WindowServer 4 (Apple)
  airportd 1 (Apple)
  mDNSResponder 0 (Apple)
  locationd 0 (Apple)
Virtual Memory Information:
  Physical RAM: 16 GB
  Free RAM: 4.26 GB
  Used RAM: 6.54 GB
  Cached files: 5.21 GB
  Available RAM: 9.46 GB
  Swap Used: 0 B
Software Installs (past 60 days):
  Install Date Name (Version)
  2024-11-20 XProtectPlistConfigData (5283)
Clean up:
  ~/Library/LaunchAgents/com.adobe.ccxprocess.plist
    /Applications/Utilities/Adobe Creative Cloud Experience/CCXProcess/CCXProcess.app
    Executable not found
Diagnostics Information (past 60 days):
  2024-12-17 07:10:31 com.apple.WebKit.WebContent Crash (17 times)
    First occurrence: 2024-12-09 20:20:38
    Details:
      Bundle controller class:
      BrowserBundleController
  2024-12-17 06:20:34 SophosUpdater.app High CPU Use (10 times)
    First occurrence: 2024-12-09 11:04:52
    Executable: /Library/Sophos Anti-Virus/SophosUpdater.app
  2024-12-16 18:39:53 xrdd High CPU Use (3 times)
    First occurrence: 2024-12-10 19:39:41
  2024-12-16 09:00:26 mdworker High CPU Use (8 times)
    First occurrence: 2024-12-10 07:05:04
    Executable: /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/Metadata.framework/Versions/A/Support/mdworker
  2024-12-15 13:00:46 signpost_reporter High CPU Use (6 times)
    First occurrence: 2024-12-09 12:31:50
    Executable: /usr/libexec/signpost_reporter
  2024-12-15 07:25:27 Capture One 23.app High CPU Use (9 times)
    First occurrence: 2024-12-10 18:48:37
    Executable: /Applications/Capture One 23.app
    Details:
      Caught a SIGTERM. Calling abort() to get a crash report from the syste
      m.
      abort() called
  2024-12-12 15:06:50 Firefox.app High CPU Use (2 times)
    First occurrence: 2024-12-12 06:01:36
    Executable: /Applications/Firefox.app