The word TWAIN is from Kipling's "The Ballad of East and West" - "...and never the twain shall meet...", reflecting the difficulty, at the time, of connecting scanners and personal computers. It was up-cased to TWAIN to make it more distinctive. This led people to believe it was an acronym, and then to a contest to come up with an expansion. None were selected, but the entry "Technology Without An Interesting Name" continues to haunt the standard.
http://www.twain.org/